Dr Kaialy (BPharm, MPhil, PhD, FHEA) obtained his BPharm degree in Damascus University where he was awarded five Academic-Excellence awards (2003 to 2007) and an overseas summer training scholarship award (T3 Pharmaceuticals, Cairo, Egypt). He graduated on 2007 with the honour of the Top Graduate student. He has been a qualified pharmacist since 2007 and worked as a pharmacy manager from 2007 to 2008. Then, he worked as a teaching assistant in the Pharmaceutics and Pharmaceutical Technology Department at the School of Pharmacy, University of Damascus, Syria from 2008 to 2009. He completed his PhD studies on pharmaceutics-drug delivery in 2013 at the University of Kent (UK) in collaboration with Pfizer (Sandwich, UK). He held a research associate postdoctoral post at University in Kent, UK (2013) where he did consultancies for Teva Pharmaceutical Industries LTD (USA). Waseem has been a Visiting Research at Luleå University of Technology (Sweden), holding an ERAS Fellowship (University of Wolverhampton), and a fellowship of the higher education academy (FHEA). In 2014, he was appointed as a Lecturer/Senior lecturer in pharmaceutics at University of Wolverhampton, UK.
Dr Kaialy has an extended knowledge in pharmaceutical science and a significant experience of high-quality teaching/supervision in Higher Education at UG and PG level since 2008. He is currently involved in a variety of research projects and collaborates with academic and industrial partners within the UK and internationally. The overall goal of his research is to improve drug delivery through understanding and enhancing the physicochemical, mechanical, and biopharmaceutical properties of pharmaceuticals. Of particular interest is particle/chemical engineering to improve the (i) aerosolisation performance of dry powder inhalers, (ii) solubility and dissolution rate of poorly soluble drugs, and (iii) and tabletability of poorly compactible drugs.
Areas of Expertise
- Pharmaceutical sciences.
- Pharmaceutics and pharmaceutical technology.
- Pharmaceutical formulation development.
- Dosage form design.
- Pharmaceutical processes.
- Drug delivery technologies.
Pharmaceutical Sciences, Pharmaceutics, Drug Delivery, Inhalation, Solid Dosage Forms, Particle Engineering.
Waseem’s ongoing research topics include particle engineering of excipients and drugs in order to improve their physicochemical, physicomechanical and biopharmaceutical properties for better oral and pulmonary delivery. The aspiration of his combined expertise in different drug delivery areas is to deliver ‘proof of concept’ for specific engineered particles and particle engineering strategies that will ultimately attain ‘concept of clinic’ approach to development of these excipients.
B. Pharm, Pharmacy Degree-Industrial Pharmacy.
Mphil, Master of Philosophy in Pharmaceutics.
PhD, Doctor of Philosophy in pharmaceutics.
ARPharmS, Associate member of the Royal pharmaceutical Society.
MAPS, Member of the Academy of Pharmaceutical Sciences.
FHEA, Associate Fellow of the higher Education Academy.
- S Shojaee, A Nokhodchi, I Cumming, A Alhalaweh, Waseem Kaialy. Investigation of drug release from PEO tablet matrices in the presence of vitamin E as antioxidant. Current drug delivery, in press.
- S Shojaee, P Emami, A Mahmood, Y Rowaiye, A Dukulay, Waseem Kaialy, I Cumming, A Nokhodchi. An Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices. AAPS PharmSciTech, in press.
- Waseem Kaialy, A Nokhodchi. Dry powder inhalers: Physicochemical and aerosolization properties of several size-fractions of a promising alterative carrier, freeze-dried mannitol (2015). European Journal of Pharmaceutical Sciences, 28, 56–67.
- Shojaee S, Waseem Kaialy, K I Cumming, A Nokhodchi. Comparative Evaluation of Drug Release from Aged Prolonged Polyethylene Oxide Tablet Matrices: Effect of Excipient and Drug Type. Pharmaceutical development and technology, in press.
- Waseem Kaialy, Maniruzzaman M, Shojaee S, Nokhodchi A (2014). Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved biopharmaceutical performance. International Journal of Pharmaceutics, 477, 282–293.
- Elsayed A, d, Mahmoud S, Al-Dadah R, Bowen J, Waseem Kaialy (2014). Experimental and Numerical Investigation of The Effect of Pellet Size on the adsorption Characteristics of Activated Carbon/Ethanol. Energy Procedia, 61, 2327 – 2330.
- Alhalaweh A, Alzghoul A, Waseem Kaialy, Mahlin D, Bergström CAS (2014). Computational Predictions of Glass-Forming Ability and Crystallization Tendency of Drug Molecules. Molecular Pharmaceutics, 11, 3123-3132.
- Waseem Kaialy, Larhrib H, Shojaee S, Nokhodchi A (2014). An approach to engineer paracetamol crystals by antisolvent crystallization technique in presence of various additives for direct compression. International journal of pharmaceutics, 464, 53-64.
- Waseem Kaialy, Hussain T, Alhalaweh A, Nokhodchi A (2014). Towards a more desirable dry powder inhaler formulation: Large spray dried mannitol microspheres outperform small microspheres. Pharmaceutical Research, 31, 60-76.
- Shojaee S, Waseem Kaialy, Nokhodchi A, Cumming I (2013). An Investigation into the Stabilization of Diltiazem HCl Release from Matrices Made from Aged Polyox Powders. AAPS PharmSciTech, 14, 1190-1198.
- Shojaee S, Cumming I, Waseem Kaialy, Nokhodchi A (2013). The influence of vitamin E succinate on the stability of polyethylene oxide PEO controlled release matrix tablets. Colloids and Surfaces B: Biointerfaces, 111, 486-492.
- Asare-Addo K, Conway BR, Hajamohaideen MJ, Waseem Kaialy, Nokhodchi A, Larhrib H (2013). Aqueous and hydro-alcoholic media effects on polyols. Colloids and Surfaces B: Biointerfaces, 111, 24-29.
- Alhalaweh A, Alzghoul A, Waseem Kaialy (2013). Data mining of solubility parameters for computational prediction of drug-excipient miscibility. Drug development and industrial pharmacy, in press, doi:10.3109/03639045.2013.789906.
- Waseem Kaialy, Emami P, Asare-Addo K, Shojaee S, Nokhodchi A (2014). Psyllium: a promising polymer for sustained release formulations in combination with HPMC polymers. Pharmaceutical Development and Technology, 19(3): 269–277.
- Hussain T , Waseem Kaialy, Deng T, Bradley M.S.A., Nokhodchi A, Armour-Chélu D (2013). A novel sensing technique for measurement of magnitude and polarity of electrostatic charge distribution across individual particles. International journal of pharmaceutics, 441, 781-789.
- Waseem Kaialy, Nokhodchi A (2013). Treating mannitol in a saturated solution of mannitol: A novel approach to modify mannitol crystals for improved drug delivery to the lungs. International journal of pharmaceutics, 448, 58-70.
- Asare-Addo K, Waseem Kaialy, Levina M, Rajabi-Siahboomi A.R., GhoriM, Supuk E, Laity P, Conway B, Nokhodchi A (2013). The Influence of Agitation Sequence and Ionic Strength on in-vitro Drug Release from Hypromellose (E4M and K4M) ER Matrices - The use of the USP III Apparatus. Colloids and Surfaces B: Biointerfaces, 104, 54-60.
- Waseem Kaialy, Nokhodchi (2013). Engineered Mannitol Ternary Additives Improve Dispersion of Lactose–Salbutamol Sulphate Dry Powder Inhalations. The AAPS Journal, 15,728-743.
- Waseem Kaialy, ShojaeeS, Nokhodchi A (2013). Anti-solvent crystallization to prepare lactose particles with enhanced dispersion performance from a dry powder inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26, A-1–A-27.
- Waseem Kaialy, Nokhodchi A (2013). Freeze dried mannitol for superior pulmonary drug delivery via dry powder inhaler. Pharmaceutical Research, 30, 458-477.
- Alhalaweh A, Waseem Kaialy, Buckton G, Gill H, Nokhodchi A, Velaga SP (2013). Theophylline Cocrystals Prepared by Spray Drying: Physicochemical Properties and Aerosolization Performance.AAPS PharmSciTech, 14, 265-276.
- Waseem Kaialy, Nokhodchi A (2012). Antisolvent crystallisation is a potential technique to prepare engineered lactose with promising aerosolisation properties: effect of saturation degree. International Journal of Pharmaceutics, 437, 57-69.
- Waseem Kaialy,Larhrib H, Ticehurst MD, Nokhodchi A (2012). Influence of batch cooling crystallization on mannitol physical properties and drug dispersion from dry powder inhalers. Crystal growth & design, 12, 3006-3017.
- Waseem Kaialy, Alhalaweh A, Velaga SP, Nokhodchi A (2012). Influence of lactose carrier particle size on the aerosol performance of budesonide from a dry powder inhaler. Powder Technology, 227, 74-85.
- Waseem Kaialy, Larhrib H, Martin GP, Nokhodchi A (2012). The effect of engineered mannitol-lactose mixture on dry powder inhaler performance. Pharmaceutical Research, 29, 2139-2156.
- Waseem Kaialy, Ticehurst MD, Nokhodchi A. Dry powder Inhalers: mechanistic evaluation of lactose formulations containing salbutamol sulphate (2012). International Journal of Pharmaceutics, 423, 184-194.
- Waseem Kaialy, Martin GP, Larhrib H, D Ticehurst MD, Kolosionek E, Nokhodchi A (2012). The influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalers. Colloids and Surfaces B: Biointerfaces, 89, 29–39.
- Waseem Kaialy, Alhalaweh A, Velaga SP, Nokhodchi A (2011). Effect of carrier particle shape on dry powder inhaler performance. International Journal of Pharmaceutics, 421, 12– 23.
- Waseem Kaialy, Ticehurst MD, Murphy J, Nokhodchi A (2011). Improved aerosolization performance of salbutamol sulphate formulated with lactose crystallised from binary mixtures of ethanol-acetone. Journal of Pharmaceutical Sciences, 100, 2665-2684.
- Waseem Kaialy, Martin GP, Ticehurst MD, Royall P, Mohammad MA, Murphy J, Nokhodchi A (2011). Characterisation and deposition studies of recrystallised lactose from binary mixtures of ethanol/butanol for improved drug delivery from dry powder inhalers. The AAPS Journal, 13, 30-43.
- Nokhodchi A, Ticehurst M.D., Mohammad M.A., Waseem Kaialy (2010). Better aerosolisation performance of salbutamol formulated with lactose crystallised from binary mixtures of ethanol/butanol. Journal of Pharmacy and pharmacology, 26, 1407-1408.
- Waseem Kaialy, G.P. Martin, M. D. Ticehurst, A. Nokhodchi (2010). Engineered mannitol as potential carrier for enhanced DPI performance. Journal of Pharmacy and pharmacology, 26, 1432-1433.
- Waseem Kaialy, Momin MN, Ticehurst MD, Nokhodchi A (2010) Engineered mannitol as an alternative carrier to enhance performance of dry powder inhaler. Colloids and Surface B-Biointerfaces, 79, 345-356.
- Waseem Kaialy, Martyn GP, Ticehurst MD, Momin MN, Nokhodchi A (2010). The enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient. International Journal of Pharmaceutics, 392, 178-188.
- Waseem Kaialy, Larhrib H, Nokhodchi A, 2014. Particle engineering for improved pulmonary drug delivery through dry powder inhalers. in: Nokhodchi A and Martin G (Eds), Pulmonary Drug Delivery: Advances and Challenges. John Wiley & Sons, Ltd., Chichester, West Sussex, UK, in press.
- Ghafourian T, Nokhodchi A, Waseem Kaialy. Surfactants as penetration enhancers for dermal and transdermal drug delivery. In press.
- Waseem Kaialy, Larhrib H, Nokhodchi A, 2011. The effect of carrier particle size on adhesion, content uniformity, and inhalation performance of budesonide using dry powder inhalers, in: Yu-Chaun Wu and Ge Wei (Ed), Particulate materials: Synthesis, Characterisation, Processing and Modelling. The Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, UK, pp.133–139.
Nokhodchi, A, Waseem Kaialy, Ticehurst, MD, 2011. The Influence of Particle Physicochemical Properties on Delivery of Drugs by Dry Powder Inhalers to the Lung, in: Popescu, M. A. (Ed), Drug Delivery, Nova Science Publishers, Hauppauge, NY, pp. 1–50