Name James Vickers
Job Title Senior Lecturer in Biomedical Science
Faculty Faculty of Science and Engineering
School School of Sciences
Subject(s) Haematology
Tel 01902 321136

Biomedical science

After finishing a first degree in pharmacology at the University of Manchester I joined the Cardiovascular Research Group at the University of Nottingham, completing my PhD on platelet-endothelial cell interactions in 1995. I then spent five years as a Postdoc researching platelet-leukocyte interactions in health and disease at the University of Jena, Germany, followed by two at Merck in Darmstadt in the cardiovascular drug development programme. From 2001 I have been working as a lecturer at the University of Wolverhampton. 

Haematology, particularly haemostasis and thrombosis, platelet function in health and disease, transfusion science and blood groups. Aggregometry, platelet function tests, flow cytometry, endothelial cell culture. Pharmacology in the 1980s. 

Platelet inhibitory drugs in acute coronary syndromes, particularly P2Y12 purinoceptor antagonists, aspirin and aspirin-like drugs. Platelet involvement in coagulation, thrombin generation in plasma. 

Lösche W, Vickers J, May J, Heptinstall S. (1991) The platelet activating activity of 2,3-diphosphoglycerate may be caused by ADP impurity. Thrombosis Research 61: 175-177

Andrews R, May J, Vickers J, Heptinstall S. (1994) Inhibition of platelet aggregation by transdermal glyceryl trinitrate. British Heart Journal 72: 575-579

Sanderson HM, Heptinstall S, Vickers J, Lösche W. (1996) Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood. Blood Coagulation and Fibrinolysis 7: 245-248

Lösche W, Redlich H, Vickers J, Spangenberg P, Krause S, Heptinstall S. (1996) Bildung von Plättchen-Leukozyten-Konjugaten und Exposition von CD62P auf der Plättchenoberfläche während der “spontanen” Plättchenaggregation. In: Zellinteraktionen, Endokrinium und Atherogenese. 
Heinle H, Schulte H und Siegel G (Hrsg.) Deutsche Gesellschaft für Atheroskleroseforschung, Blaubeuren.

Redlich H, Vickers J, Lösche W, Heptinstall S, Kehrel B, Spangenberg P. (1997) Formation of platelet-leukocyte conjugates in whole blood. Platelets 8: 419-425

Vickers J, Lösche W, Döpel E, Heptinstall S, Stein G, Spangenberg P. (1998) Measurement of platelet activation and adhesion to leukocytes during haemodialysis. Platelets 9: 261-264

Vickers J, Rußwurm S, Dohrn B, Portele T, Spangenberg P Reinhart K, Lösche W. (1998) Monocyte tissue factor (CD142) and Mac-1 (CD11b) are increased in septic patients. Thrombosis and Haemostasis 79: 1219-1220

Lösche W, Temmler U, Redlich H, Vickers J, Krause S, Spangenberg P. (2001) Inhibition of leukocyte chemiluminescence by platelets: role of platelet-bound fibrinogen. Platelets 12: 15-19

Rußwurm S, Vickers J, Meier-Hellmann A, Bredle D, Spangenberg P, Reinhart K, Lösche W. (2002) Platelet and leukocyte activation correlate with the severity of septic organ dysfunction. Shock 17(4): 263-268

Cotton JM, Worrall AM, Hobson AR, Smallwood A, Amoah V, Dunmore S, Nevill AM, Raghuraman R, Vickers J, Curzon N. (2010) Individualised assessment of response to clopidogrel in patients presenting with acute coronary syndromes: a role for short thromboelastography? Cardiovascular Therapeutics 28: 139-146