Senior Lecturer in the School of Health, James Pearson-Jenkins, and his brother Peter, who is a student at the University, are planning to walk from Birmingham to London via the Grand Union Canal.
They are raising funds for The Akabusi Charitable Trust (TACT) as James has recently been newly appointed as a TACT volunteer for research and development into health and education in Nigeria.
James, 32, from Great Bridge, Sandwell, said: "We are doing the walk on the weekend of August 28 2009 and we are hoping to complete the 145 miles in under four days.
"TACT has a history of successful projects in both water provision and sanitation in Nigeria; the 2:1 Walk for Water aims to highlight that in the UK we are very lucky to access clean, safe drinking water and also to use water for leisure purposes."
Peter Jenkins, who is in the second year of a Physician Assistant course at the University, came up with the idea of the 2:1 walk.
The 26-year-old from Wellington, Telford, said: "I knew James was exploring ideas about doing fundraising for TACT, and so I suggested a charity event with a challenge, and the 2:1 Walk for Water is certainly that. But it is also a good opportunity to highlight health problems in Nigeria."
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