Name Professor Stephen Britland
Job Title Professor and Head of the School of Pharmacy
Faculty Faculty of Science and Engineering
School School of Pharmacy
Subject(s)

Pharmacy

Tel 01902 322140
Email S.Britland@wlv.ac.uk

Stephen Britland Image

Head of Wolverhampton School of Pharmacy (2013-) Associate Dean for Research and Post-graduate Studies, Faculty of Science and Engineering (2014-)

Head of Pharmacology, Univ. of Bradford, UK (2008-2013) and Team Leader – Clinical Therapeutics, Univ. Bradford, UK (2011-2013)

Reader in Cell Biology, Univ. Bradford, UK (2003-2013)

Senior Lecturer in Pharmacology, Univ. Bradford (2001-2003)

Lecturer in Pharmacology, Univ. Bradford (1997-2001)

Research Fellow 1994-1997, Dept. of Electronics, Univ. Glasgow.

Lecturer in Neuroscience 1990-1994, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, University of London. (Awarded Recognised Teacher Status in Neuropathology 1993).

Post-doctorate research assistant 1989-1990, Depts. of Electronics and Electrical Engineering and Cell Biology, University of Glasgow.

Post-doctorate research assistant 1988-1989, Dept. of Anatomy, University of Aberdeen.

Pharmacology/Biotechnology

Throughout my career the scope of my interests and outputs has been broad and included advanced microscopical techniques for interface imaging (funded by EPSRC), point-of-care diagnostics for chronic wound management (funded by TSB/AGT Sciences Ltd), in vitro pharmacological models of skin disease (funded by Reckitt Benckiser Ltd), mimetic cartilage replacement devices (funded by Yorkshire Forward/AGT Sciences Ltd), pulmonary drug delivery (White Rose Health Innovation Partnership), infection control (Industry/USA), magnetophoretic drug delivery (Industry/Australia), stem cell work (EPSRC/China Bridges) and lastly the area that has generated most media interest work on the biochemistry of Lucilia Serricata biotherapy in wound management and its application to biotechnology (TSB/DTI/AGTS sciences Ltd.). I’m currently working with the ‘ceutics team at Wolverhampton School of Pharmacy in the areas of drug delivery in wound management and pharmaceutical engineering applications for personalised medicine.

Member of a NIHR Healthcare Technology Strategic Partnership. April 2012. Work Stream: Experience Based Co Design for wound care devices, technologies, technology-dependent interventions. Director: Professor Peter Vowden, BIHR, Bradford Royal Infirmary. Co- applicants: S. Britland Pharmacy Wolverhampton; J. Nixon and A. Nelson, Leeds University; P.Grocott and R. Glenn, King’s College London; J. Steven, Birmingham NHS Trust.

Fellow of the Higher Education Academy (2007-)

Member of the Academic Pharmacy Group, RPSGB/RPS (1997-)

Al-Ani, E., Hill, D.J., Britland, S.T., Amin, M.C.I.M and Martin, C.  Mucoadhesive buccal tablets based on hydroxypropyl methylcellulose (HPMC) and poloxamer 407 (P407) for controlled delivery of chlorhexidine.  Colloids and Surfaces B: Biointerfaces.  Submitted June 2016.

Gupta, A., Low, W.L., Radecka, I., Britland, S.T., Amin, M.C.I.M., and Martin, C.  Development and characterisation of silver-loaded bacterial cellulose for antimicrobial hydrogel wound dressing applications.  Journal of Microencapsulation accepted June 2016.

Low, W.L., Kenward, M.A., Britland, S.T., Amin, M.C.I.M. and Martin, C. (2016).  Essential oils and metal ions as alternative antimicrobial agents: A focus on tea tree oil and silver.  International Wound Journal.  In press.  Available at http://dx.doi:10.1111/iwj.12611.

Martin, C., Low, W.L., Gupta, A., Amin, M.C.I.M., Radecka, I., Britland, S.T., Raj, P. and Kenward, M.A. (2015).  Strategies for Antimicrobial Drug Delivery to the Biofilm.  Current Pharmaceutical Design, 21 (1): 43-66.

Martin, C., Low, W. L., Gupta, A., Amin, M. C. I. M., Radecka, I., Britland, S T., Raj, P. and Kenward, M. A. (2015). Strategies for Antimicrobial Drug Delivery to the Biofilm. Current Pharmaceutical Design 21:43-66.

Liposome encapsulated Disulfiram targets breast cancer stem cells in vitro and in vivo (2014) Peng Liu, Zhipeng Wang, Sarah Brown, Vinodh Kannappan, Patricia Erebi Tawari, Wenguo Jiang, Juan M. Irache, James Z. Tang, Stephen Britland, Angel L. Armesilla, John L. Darling, Xing Tang and Weiguang Wang. Oncotarget 5:7471-7486.

Sensitivity and specificity of the empirical lymphocyte genome sensitivity (LGS) assay: implications for improving cancer diagnostics (2014). Anderson D, Najafzadeh N, Gopalan R, Ghaderi N, Scally A, Britland S, Jacobs B, Reynolds P, Davies J, Wright A, Al-Ghazal S, Sharpe D, Denyer M. FASEB (10):4563-70.

Martin, C., Low, W. L., Gupta, A., Amin, M. C. I. M., Radecka, I., Britland, S. T., Raj, P., and Kenward, M. A. (2014). “Liposomal Delivery of Antimicrobials” in Advances in Liposome Research (part of the Biochemistry Research Trends series) edited by Laura Finney. Nova Science Publishers Inc., New York, pp 27 – 61. ISBN 978-1-63117-074-4.

Interfacial study of cell adhesion to liquid crystals using widefieldsurface plasmon resonance microscopy. (2013) Chin Fhong Soona, Seyed Ali Khaghanic, Mansour Youseffic, Nafarizal Nayana,Hashim Saima, Stephen Britland, Nick Blagden, Morgan Clive Thomas Denyer. Colloids and Surfaces B: Biointerfaces 110:156– 162.

Droplet aerodynamics, cellular uptake and efficacy of a nebulizable corticosteroid nanosuspension compared with a micronized dosage form. (2012). Britland S, Finter W, D Chrystyn H, Eagland D, Emam M . Biotechnology Progress 28:1152-1159.

The lactate conundrum in wound healing: clinical and experimental findings indicate the requirement for a rapid point-of-care diagnostic (2012) Britland, S.T., Ross-Smith, O., Smith, A.G., Vowden, K., Vowden P. Biotechnology Progress 28:917-924.

Transcriptional gene silencing of kallikrein 5 and kallikrein 7 using siRNA prevents epithelial cell detachment induced by alkaline shock in an in vitro model of eczema (2012). Stephen Britland, Milli Hoyle. Biotechnology Progress 28:485-489.

Recombinant Lucilia Sericata chymotrypsin in a topical hydrogel formulation degrades human wound eschar ex vivo. (2011) Britland S, Smith A, Finter W, Eagland D, Vowden K, Vowden P, Telford G, Brown A, Pritchard D. Biotechnology Progress. 27:870-874.

The involvement of serotonergic transmission system in neonatal and adult rat ileum contractility varies with gestational age. (2011) Batista-Lobo, S., Denyer, M. Britland, S.T., Javid, F. Pharmacology 88:225-232

Chrystyn, Henry, Abdelmoby, M, Eagland, D, Nadarassan, D.K. and Britland, S. T. (2009) Improved Pulmonary Delivery and Retention of a Budesonide Nanagel Clear Solution. In: RDD Europe 2009. Davis Healthcare International, pp. 405-408. ISBN 1933722312

High resolution imaging of the cell surface interface using the new wide-field surface plasmon microscope (2008) M. Mahadi Abdul Jamil1, M.C.T. Denyer1, M. Youseffi1, S.T. Britland1, S. Liu2, C.W. See2, M.G. Somekh2 and J. Zhang2. Journal of Structural Biology 164:75-80. ISSN1047-8477.

High resolution bio-molecular binding studies using a novel wide-field surface plasmon microscope (2008) M. Mahadi Abdul Jamil, M. Youseffi, S.T. Britland, S. Liu, C.W. See, M.G. Somekh, S. Marlafeka, M.C.T. Denyer. Sensors and Actuators B 129:566-574. ISSN0925-4005.

Cell Imaging with a wide-field surface plasmon microscope (2008) M.M. Abdul Jamil, F. Sefat, S.A. Khaghani, S.B. Lobo, F.A. Javid, M. Youseffi, S.T. Britland, S.G. Liu, C.W. See, M.G. Somekh, M.C.T. Denyer. IFMBE Proceedings 21:528-531 ISSN1680-0737

Development of an intestinal cell culture model to obtain smooth muscle cells and myenteric neurons (2007) S. Batista Lobo., M. Denyer., S. Britland., F.A.Javid. Journal of Anatomy 211:819-829. ISSN 0021-8782.

Microengineered surface topography facilitates cell grafting from a prototype hydrogel wound dressing with anti-bacterial capability (2006) Annie G. Smith1, Abbas Din1, Morgan Denyer1, Nicholas J. Crowther2, Donald Eagland2, Kath Vowden3, Peter Vowden3, Stephen T. Britland1,2* Biotechnology Progress 22:1407- 1415. ISSN: 8756-7938

Greenbottle (Lucilia Sericata) larval secretions delivered from a prototype hydrogel wound dressing accelerate the closure of model wounds (2006) Annie G. Smith, Rachel A. Powis, David I. Pritchard, Stephen T. Britland. Biotechnology Progress 22:1690-1696. ISSN: 8756-7938

Polyvinyl alcohol hydrogel as a visco-elastic mimetic for articular cartilage (2006) Colin Grant1, Pete Twigg1*, Alex Egan2, Alexandra Moody2, Annie Smith2, Donald Eagland3, Nicolas Crowther3, Steve Britland2,3 Biotechnology Progress 22:1400-1406.

Microengineered hydrogel as a vehicle for grafting human skin cells. (2006) Stephen Britland, Annie Smith, Nick Crowther, Donald Eagland, Kath Vowden, Peter Vowden. EWMA Journal 6:12-15. ISSN 1609-2759.

Imaging biomolecular nanofilms at micrometer lateral resolution using widefield surface plasmon microscopy (2006) S. Marlafeka1, S.T. Britland1, S. Liu3, P.C. Twigg2, C.W. See3, M.G. Somekh3 and M.C.T. Denyer1. IFMBE Proceedings Singapore, 12:3B2-03. ISSN-1727-1983

Widefield surface plasmon resonance microscopy: a novel biosensor study of cell attachment to micropatterned surfaces. (2006) M. Mahadi Abdul Jamil, M. Youseffi, S.T.Britland, S.Liu, C.W.See, M.G. Somekh, M.C.T.Denyer. IFMBE Proceedings 15:286-290.

High resolution TGF-beta-treated human keratinocytes via a newly- developed widefield surface plasmon resonance microscope. (2006) M. Mahadi Abdul Jamil, M. Youseffi, S.T.Britland, S.Liu, C.W.See, M.G. Somekh, M.C.T.Denyer. IFMBE Proceedings 15:286-290.

Development of technology for point of care diagnostics through to cell-based therapy for chronic wounds (2005) Stephen Britland, Annie Thomas, Abbas Din, Annie Smith, Nick Crowther, Donald Eagland. European Tissue Repair Society Bulletin 12;113-116. ISSN1380-3433.

S. Marlefeka, S, Lui, M.Mahadi Abdul Jamil, P.C.Twigg, S.T. Britland, M.C.T. Denyer, C.W. See, M.G. Somekh. (2005) Application of a novel widefield surface plasmon resonance microscope in binding assays. Proceedings of the 3rd IEEE/EMB Special Topic Conference on Microtechnologies in Medicine. pp140-142. ISBN0- 7803-8712-0

J Sutherland, AG Smith, AC Egan, MC Denyer and ST Britland. (2005) Control of human skin cell adhesion, proliferation and migration by microengineered substrata: transposition from solid phase to clinically relevant materials. Proceedings of the 3rd Annual International IEEE/EMB Special Topic Conference on Microtechnologies in Medicine. pp190-193. ISBN0-7803-8712-0

Sutherland, J., Denyer, M., Britland, S.T. (2005) Contact guidance in human dermal fibroblasts is modulated by population pressure. Journal of Anatomy 206:581-587. ISSN0021-8782.

Sutherland, J., Denyer, M., Britland, S.T. (2005) Motogenic substrata and chemokinetic growth factors for human skin cells. Journal of Anatomy 207:67-78. ISSN0021-8722

Evans, DJR., Britland, S., Wigmore, PM (1999) Differential response of fetal and neonatal myoblasts to topographical guidance cues in vitro. Development Genes and Evolution. 209:438-442. ISSN0949-944X.

Sprössler, C., Denyer, M. C., Britland, S. T., Knoll, W., Offenhausser, A. (1999) Electrical recording from rat cardiac muscle cells using field-effect transistors. Physical Reviews in Electronics 60, 2171-2176. ISSN 1063-651X.

MCT Denyer, M Riehle, J Hayashi, M Scholl, C Sproessler, ST Britland, A Offenhauser, W Knoll (1999) Bioassay development: the implications of cardiac myocyte motility in vitro. In Vitro Cellular & Developmental Biology-Animal 35:352-356. ISSN 1071-2690.

S Archer, T-T Li, AT Evans, ST Britland, H Morgan (1999) Cell reactions to dielectrophoretic manipulation. Biochemical and Biophysics Research Communications 257:687-698. ISSN 0006-291X.

Denyer MCT, Riehle M, Britland ST, Offenhauser A. (1998) Preliminary studies of a pharmacological bio-assay based on cardiac myocytes cultured over microfabricated microelectrode arrays. Medical and Biological Engineering and Computing 36 (5):638-644. ISSN 0021-9533.

Denyer M, Britland S, Curtis ASG, Wilkinson CDW (1997) Patterning living neural networks on microelectronic electrophysiological recording devices. Cellular Engineering 2:122-131. ISSN 1357-5481.

Contact guidance of CNS neurites on grooved quartz: influence of groove dimensions, neuronal age and cell type (1997) Rajnicek A, Britland S, McCaig CD. J. Cell Sci. 110:2905-2913. ISSN 0021-9533.

Some basic cell biology for neuro-prosthetic microdevices (1996) Curtis, A., Britland S, Denyer M, Alef A.. Proc. 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Bridging Disciplines for Biomedicine 1: 385-6. (Cat. No.96CH36036).

Britland ST, Wojiak-Stodart B, Morgan H, Curtis A, Wilkinson C (1996) Synergistic and hierarchical adhesive and topographic guidance in BHK cells. Exp. Cell Res. 228:313-325. ISSN 0014-4827.

Britland ST and McCaig CD (1996) Embryonic Xenopus neurites integrate and respond to simultaneous electrical and adhesive guidance cues. Exp. Cell Res.226:31- 38. ISSN 0014-4827.

Britland ST, Perridge C, Morgan H, Denyer M, Curtis A, Wilkinson C (1996) Morphogenetic guidance cues can interact synergistically and hierarchically in steering nerve cell growth. Exp. Biol. Online 1:2 (access through http://science.springer.de) ISSN 1430-3418.

Adam Curtis and Stephen Britland (1996) Surface modification of biomaterials by topographic and chemical patterning. In: Advanced Biomaterials in BiomedicalEngineering and Drug Delivery Systems (eds) N. Ogata, S.W. Kim, J. Feijen, T. Okano. Springer-Verlag, Tokyo, pp158-162.

Clark P, Britland ST, Connolly P (1993) Growth cone guidance and neuron morphology on micropatterned laminin surfaces. J. Cell Sci.105:203-212. ISSN 0021- 9533.

Britland ST (1993) Neuropathology in diabetes mellitus: lessons from experimental models. In: Diabetes mellitus and its complications. An update. (Eds) Sharma AK, Mehra NK, Behara M, Abdulrazzaq Y, Galadari 1, Ward J. MacMillan Publishers, pp295-302.

Britland ST, Perez-Arnaud E, McGinn B, Connolly P, Moores G (1992). Micropatterning proteins and synthetic peptides on solid supports: a novel application for microelectronics fabrication technology. Biotechnology Progress 8: 155-160. ISSN 8756-7938.

Connolly P, Moores G, Monaghan W, Shen J, Britland ST, Clark P (1992) Microelectronic and nanoelectronic interfacing techniques for biological systems. Sensors and Actuators 6: 113- 121. ISSN 0925-4005.

Britland ST, Clark P, Connolly P, Moores G (1992) Micropatterned substratum adhesiveness: a model for morphogenetic cues controlling cell behaviour. Exp. Cell Res. 198:124-129. ISSN 0014-4827.

Britland ST, Young RJ, Sharma AK, Clarke BF (1992) Acute and remitting painful diabetic neuropathy: a comparison of peripheral nerve fibre pathology. Pain 48:361- 370. ISSN 0304-3959. Journal cover illustration.

Connolly P, Britland ST, Clark P, Monaghan W, Moores GM (1991) Microelectronic and nanoelectronic interfacing techniques for biological systems. In: Progress in Precision Engineering. (Eds) Seyfried P, Kunzmann H, McKeown P, Weck M. Springer-Verlag, NY. pp225-230.

Britland ST, von Zimmerman 0, Sharma AK, Bretzel RG, Federlin K (1991) The effect of pancreatic islet transplantation on experimental diabetic neuropathy. J. Neurol. Sci. 105: 168-174. ISSN 0022-510X.

Britland ST, Sharma AK (1990) A comparison of the effects of conventional insulin treatment and continuous insulin infusion therapy on established morphological and biochemical abnormalities of peripheral nerve in experimental diabetes. Diabetes Research 15:143-150.

Britland ST and Sharma AK (1990) A new perspective on myelinated nerve fibre pathology in experimental diabetes. Diabetes Research 15:69-75.

Britland ST, Young RJ, Sharma AK, Clarke BF (1990) Association of painful and painless diabetic polyneuropathy with different patterns of nerve fiber degeneration and regeneration. Diabetes 39:898-908. ISSN 0012-1797.

Britland ST, Young RJ, Sharma AK, Clarke BF (1990) Relationship of endoneurial capillary abnormalities to type and severity of diabetic polyneuropathy. Diabetes 39: 909-913. ISSN 0012-1797.

Britland ST, Young RJ, Sharma AK, Lee D, Ah-See AK, Clarke BF (1990) Vagus nerve morphology in diabetic gastropathy. Diabetic Medicine 7:780-787. ISSN 0742- 3071.

Sharma AK, Britland ST (1990) Peripheral nerve structure in experimental diabetes: the effect of various therapies. In: Diabetic Neuropathy. (Eds) Ward JD, Goto Y. Wiley and Sons Ltd., London, pp47-65.

Sharma AK, Britland ST, Young RJ, Malik RA, Newrick PG, Boulton AJM, Ward JD (1990) Morphological abnormalities in the sural nerves of diabetic patients with and without clinical syndromes of diabetic neuropathy. In: Diabetic Neuropathy. (Eds) Ward JD, Goto Y. Wiley and Sons Ltd., London, pp29-45.

Britland ST, Sharma AK, Duguid IGM, Thomas PK. (1985) Ultrastructural observations on myelinated nerve fibres in the tibial nerve of STZ-diabetic rats: effect of insulin treatment. Journal of the European Society for Artificial Organs 3 (Suppl. 1): 524-529