Name Dr Stephanie Myers
Job Title Lecturer in Pharmaceutical Chemistry
Faculty Faculty of Science and Engineering
School School of Pharmacy
Subject(s)

Pharmaceutical Science, Pharmacy

Tel 01902 51 8655
Email S.Myers@wlv.ac.uk

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Stephanie studied BSc. Chemical and Pharmaceutical Science at the University of Sunderland, graduating with Honours in 2007. During the course of her degree, she joined GlaxoSmithKline in Hertfordshire as an industrial placement student working in the Psychiatry Centre of Excellence for Drug Discovery to investigate pharmacokinetic properties of new-generation atypical antipsychotic drugs.

 

Following completion of her Bachelor’s degree, she received a Master’s degree in Drug Chemistry at Newcastle University with Distinction, followed by a PhD in Medicinal Chemistry funded by Cancer Research UK, under the supervision of Dr Celine Cano and Dr Ian Hardcastle within the Northern Institute of Cancer Research (NICR).

 

Stephanie rejoined the NICR in March 2013 as a Research Associate funded by the Medical Research Council (MRC), working towards the discovery of inhibitors of the kinase ERK5 for biomarker-driven clinical evaluation in cancer, in collaboration with Cancer Research Technology (CRT), the Babraham Institute and Astex Pharmaceuticals.

 

In August 2014 Stephanie moved to the Institute of Cancer Research (ICR), one of the world’s most influential cancer research organisations, joining the team of Professor Ian Collins. Stephanie joined the team as a Research Training Fellow to optimise inhibitors of inositol-requiring enzyme 1 (IRE-1), a dual kinase-endonuclease enzyme. Stephanie then became the leading chemist on new project to identify kinesin-like protein KIFC1 (HSET) inhibitors (hit-generation and lead-identification).

 

Stephanie went on to join the University of Wolverhampton in September 2016 as a lecturer in Pharmaceutical Chemistry and is presently involved in teaching on the MPharm, BSc Pharmaceutical Science, Faculty of Science and Engineering Foundation Year and MSc Pharmaceutical Science courses within the School of Pharmacy.

 

In her spare time, Stephanie enjoys participating in public engagement activities and acts as a STEM ambassador, encouraging young people to pursue careers in science. 

Organic Chemistry

Pharmaceutical Chemistry

Medicinal Chemistry

Pharmaceutical Analysis

Drug Discovery

Drug Design

Cancer Research

Development of small-molecule inhibitors of kinases and kinesins for the treatment of cancer 

 

Associate Member of the Royal Society of Chemistry

STEM Ambassador

Journal Articles

Myers, S.M., Bawn, R.H., Bisset, L.C., Blackburn, T.J., Cottyn, B., Molyneux, L., Wong, A.C., Cano, C., Clegg, W., Harrington, R.W., Leung, H., Rigoreau, L., Vidot, S., Golding, B.T., Griffin, R.J., Hammonds, T., Newell, D.R, Hardcastle, I.R., Screening and Hit Validation Studies for Extracellular Signal-Regulated Kinase 5 (ERK5) Inhibitors, ACS Comb. Sci. 2016, 18, 444-455.

Patents

Reuillon, T., Miller, D., Myers, S., Molyneux, L., Cano, C., Hardcastle, I., Rigoreau, L., Golding, B., Noble, M., Griffin, R. Pyrrolcarboxamide derivatives for the inhibition of ERK5, PCT Int. Appl. 2016, WO/2016/042341.

 

Literature Reviews

Myers, S.M., Collins, I., Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy, Future Medicinal Chemistry, 2016, 8, 463-489.

 

Oral Communications

  1. S. Myers, Hit Identification and Evaluation of HSET Inhibitors, The Institute of Cancer Research Department of Cancer Therapeutics Research Meeting, London, February 2016

 

  1. S. Myers,Hit Validation and Development of ERK5 Inhibitors: Expectations and Challenges, The Institute of Cancer Research Chemistry Department Seminar, May 2015

 

  1. S. Myers, M. Day, N. Edwards, Mitogen-Activated Protein Kinase ERK5, Newcastle Cancer Centre and NICR Drug Discovery and Imaging Research Group Retreat, Newcastle, January 2014

 

  1. S. Myers, Protons to Patients: How a ‘mini-cyclotron’ will make a big impact on cancer research – Drug Discovery, British Science Festival Lecture, New Research and Technology Section, Newcastle Upon Tyne, September 2013

 

  1. S. Myers, Hit Validation of ERK5 Inhibitors: Expectations and Challenges, 5th Biological and Medicinal Chemistry Symposium, Cambridge University, December 2011, honourable mention for excellent communication skills

 

  1. S. Myers, The Identification and Synthesis of 3-Cyanopyridines as Inhibitors of Extracellular Signal-Regulated Kinase 5, Postgraduate Research Symposium, Newcastle University, July 2011

 

  1. S. Myers, Small Molecule Inhibitors of ERK5, Cancer Research UK Drug Discovery and Imaging Retreat, Newcastle, March 2011

 

  1. S Myers, Small Molecule Inhibitors of ERK5, Cancer Research UK Drug Discovery and Imaging Retreat, Durham, March 2010

 

 

Poster Communications

 

S. Myers, R. Bawn, T. Blackburn, L. Barrett, N. Martin, T. Reuillon, B. Golding, R. Griffin, T. Hammonds, I. Hardcastle, H. Leung, D. Newell, L. Rigoreau, A. Wong, C. Cano, Development of ERK5 inhibitors for anti-cancer therapy.

  1. 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona, Spain, November 2014
  2. 10th NCRI Cancer Conference, Liverpool, November 2014

 

S. Myers, L. Barrett, R. Bawn, T. Blackburn, B. Cottyn, B.T. Golding, R.J. Griffin, T. Hammonds, H. Leung, N.C. Martin, D.R. Newell, L. Rigoreau, A. Wong, C. Cano and I.R. Hardcastle, Hit Validation of ERK5 Inhibitors: Expectations and Challenges.

  1. RSC Bioorganic Group Postgraduate Symposium, University of Manchester, April 2013
  2. ACS National Meeting and Expo, San Diego, March 2012
  3. RSC Organic Division North East Regional Meeting, University of Huddersfield, March 2013

 

S. Myers, B. Cottyn, R.J. Griffin, T. Hammonds, H. Leung, D.R Newell, L. Rigoreau, A. Wong, C. Cano and I.R. Hardcastle,  The Development of 3-Cyanopyridines as ERK5 Inhibitors.

  1. RSC Chemical Tools in Systems Biology Meeting, London, September 2011
  2. Cancer Research UK Annual Student’s Meeting, London, April 2011
  3. 4th Biological and Medicinal Chemistry Symposium, Cambridge University, December 2010
  4. Cancer Research UK Medicinal Chemistry Workshop, Newcastle University, December 2010
  5. Protein Kinase 2010: Signalling Success, Cambridge, October 2010
  6. Pre-Grasmere Meeting and RSC Endowed Lecture Symposium, York, May 2009

 

Other Poster Contributions:

 

  1. T. McHardy, K. Boxall, M. Liu, M. Richards, S. Myers, S. Linardopoulos, I. Collins, Kinetic Solubility – an important parameter assessed in the early stages of HSET hit compound development, ICR.

 

  1. N.C. Martin, S. Myers, R. Bawn, B. Cottyn, T. Blackburn, L. Barrett, B.T. Golding, R.J. Griffin, T. Hammonds, H. Leung, D. Newell, L. Rigoreau, A-C. Wong, I.R. Hardcastle, C. Cano, Development of ERK5 Inhibitors for Anti-Cancer Therapy, NICR.

 

  1. S. Adhikari, A. Bertoli, S.J. Harnor, S. Myers, S. Tudhope, Y. Zhao, A. Wittner, E. Wilmore, J. Lunec, D.R. Newell, S.R. Wedge, I.R. Hardcastle, B.T. Golding, C Cano, and R.J. Griffin, Validation Studies with Small-Molecule Modulators of the MDM2/MDMX-p53 Binding Interaction, NICR.

 

  1. P.M. Woollard, S. Myers, P. Sadra, Measurement and Calculation of Brain Tissue Binding – Consequence for Compounds with Very Low Binding, GSK.

 

Public Engagement

 

  1. S Myers, Medicinal properties of the Opium poppy, Papaver Somniferum, Wolverhampton Community Radio (WRCfm) segment, November 2016

 

  1. L. Burtally, Using Kinesin Inhibitors to Unmask Cancer, ICR Blog http://www.icr.ac.uk/blogs/science-talk-the-icr-blog/page-details/using-kinesin-inhibitors-to-unmask-cancer, June 2016

 

  1. S. Myers, A. Antolin, T. McHardy, R. Rogers, Public Engagement at the Royal Holloway Science Festival, London, March 2016

 

  1. S. Myers, Women in STEM Event, Cheam High School, London, December 2015

 

  1. S. Myers, Drug Discovery at the Northern Institute for Cancer Research, CRUK Fundraisers Evening, Northern Institute for Cancer Research, November 2013

 

  1. S. Myers, S. Kyle, G. Junge, M. Buckingham, Hitting the Spot! Targeting Cancer Treatments, Public Engagement at the Celebrate Science Event, Durham University, October 2013

 

  1. S. Myers, E. Mould, BBC Radio Five Live Interview focussing on Cancer Research at the NICR, October 2013

 

  1. S. Myers, Protons to Patients: How a ‘mini-cyclotron’ will make a big impact on cancer research – Drug Discovery, British Science Festival Lecture, New Research and Technology Section, Newcastle Upon Tyne, September 2013