Brain Tumour UK Neuro-oncology Research
Brain tumours are the sixth most common cancer in
adults, accounting for 2% of all tumours, and the most common form
of solid cancer in children.
The overall incidence of such tumours in the UK is of the order
of 10-20 cases per 100,000. They are a significant cause of cause
of neurological morbidity and mortality in all age groups and there
is an urgent requirement to develop new effective therapeutic
strategies based on their intrinsic molecular biology.
In our research programme, we are integrating our expertise in
genetic and cell biological analysis to provide a unique insight
into the mechanisms of tumour development and clinical behaviour
(eg tumour recurrence, malignant progression, response to therapy
and overall survival) and to develop new therapies for brain
tumours based on an understanding of their genomic background.
One of the key components to developing and evaluating novel
treatment strategies is the ability to test their efficacy in
The Neuro-Oncology Research Centre has an internationally
unrivalled collection of short-term cell cultures (>3000)
derived from brain tumours of different histologies and grades of
These cultures can be used to test new cytotoxic compounds or
novel combinations of drugs which act synergistically. We can also
modulate the tumour cell environment (eg availability of nutrients
and oxygen) or manipulate the expression of molecular targets (eg
signalling pathway components) in order to evaluate the effect on
cell proliferation and behaviour.
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